Mark J. Snider
The Robert E. Wilson Professor of Chemistry Chair, Biochemistry & Molecular Biology Program
Biography
Areas of Interest
- Mechanistic and structural enzymology of bacterial degradation of nicotinic acid.
- Using stopped-flow spectrophotometry to investigate kinetic mechanisms of flavin monooxygenases.
- Functional characterization of novel phosphagen kinases, with the goal of discerning the evolution of substrate specificity, cooperative substrate binding and quaternary structure.
Courses Taught
- CHEM 101: Chemistry and the World in Which We Live
- CHEM 111: General Chemistry I
- CHEM 112: General Chemistry II
- CHEM 399: Biophysical Chemistry
- BCMB 303: Techniques in Biochemistry & Molecular Biology
- BCMB 331: Principles of Biochemistry
- BCMB 332: Biochemistry of Metabolism
- BCMB 401: Introduction to Independent Study
- IDPT 101: First Year Seminars in Critical Inquiry
Selected Publications & Presentations
- B. C. Richardson, Z. R. Turlington, S. V. Ferreira de Macedo, S. K. Phillips, K. Perry, S. G. Brancato, E. W. Cooke*, J. R Gwilt, M. Dasovich*, A. J. Roering, F. M. Rossi, M. J. Snider, J. B. French and K. A. Hicks (2024) Structural and functional characterization of a novel class A flavin monooxygenase from Bacillus niacini. Biochemistry 63: 2391-2532. DOI
- Z. R. Turlington; S. V. Ferreira de Macedo; K. Perry; S. L. Belsky*; J. A. Faust; M. J. Snider and K. A. Hicks (2024) Ligand bound structure of a 6鈥恏ydroxynicotinic acid 3鈥恗onooxygenase provides mechanistic insights; Archives in Biochemistry & Biophysics 752; 109859. DOI
- S. W. Perkins*, M. Z. Hlaing*, K. A. Hicks, L. Rajakovich, M. J. Snider (2023) Mechanism of the multi-step catalytic cycle of 6-hydroxynicotinate 3-monooxygenase revealed by global kinetic analysis; Biochemistry 62; 1553-1567.
- P. Piper*, B. Begres*, M. Snider, D. Fraga (2020) Two cryptosporidia species encode active creatine kinases that are not seen in other Apicomplexa species; Comparative Biochemistry and Physiology 鈥� Part B 246, 110459.
- K. D. Nakamoto*, S. W. Perkins*, R. G. Campbell*, M. R. Bauerle*, T. G. Gerwig*, S. Gerislioglu, C. Wesdemiotis, M. A. Anderson, K. A. Hicks, M. J. Snider (2019) Mechanism of 6-hydroxynicotinate 3-monoxygenase, a flavin-dependent decarboxylative hydroxylase involved in aerobic nicotinic acid degradation. Biochemistry 58; 1751-1763.
- K. A. Hicks, M. E. Yuen, W.- F. Zhen, T. J. Gerwig*, R. W. Story*, M. Kopp, M. J. Snider (2016) Structural and biochemical characterization of 6-hydroxynicotinic acid 3-monooxygenase, a novel decarboxylative hydroxylase involved in aerobic nicotinate degradation. Biochemistry 55, 3432鈥�3446.
Presentations
- Mark J. Snider and Katherine A. Hicks (2024) Novel enzymology of nicotinic acid degradation in Bacillus niacini. , Naples, FL, January 2024.
- Mark J. Snider, Jack Redick, May Hlaing and Lauren Rajakovich (2023) Probing substrate specificity in the class A flavin enzyme 6-hydroxynicotinate 3-monooxygenase; Midwest Enzyme Chemistry Conference, Northwestern University, Evanston, IL, September 2023
Independent Study Advising
- Takoda Zuehlke (2023) BCMB: Identification of a putative binding mechanism for the reducing substrate of 6-hydroxynicotinate 3-monooxygenase
- May Z. Hlaing(2022) BCMB: Investigating substrate specificity for 6-hydroxynicotinate-3-monooxygenase (NicC) with alternative substrates: consequences to catalysis of replacing or removing the ring nitrogen
- Robert Beal (2022) BCMB: Role of tight binding in negative cooperativity in the dimeric mitochondrial taurocyamine kinase from Arenicola brasiliensis
Awards & Honors
- National Science Foundation (2018-present), Molecular Biophysics Program RUI: Collaborative Research: Enzymology of Bacterial Nicotinic Acid Catabolism by Mark Snider (PI), Katherine Hicks (PI, SUNY Cortland) $ 551,536.
- National Science Foundation (2016-2019), Major Research Instrumentation Program Acquisition of an NMR Spectrometer to Sustain Excellence in Undergraduate Research with Paul Bonvallet (PI), Judith Amburgey-Peters, Spring Knapp and Sarah Sobeck
- Research Corporation for Science Advancement: Multi-Investigator Cottrell College Science Award Program (2012-2014), 鈥淏acterial Degradation of Pharmaceuticals and Personal Care Products During Waste Water Treatment鈥� with Stephanie Strand (Biology) and Melissa Schultz (Chemistry).
- National Science Foundation (2008-2011), 鈥淎cquisition of an LC/MS/MS to Enhance Undergraduate Research and Teaching鈥� with Melissa Schultz and Paul Edmiston (Chemistry).
- National Science Foundation (2006-2009), 鈥淎cquisition of an Isothermal Titration Calorimeter鈥� with Paul Bonvallet (Chemistry) and Don Jacobs (Physics).
- National Science Foundation (2004-2007), 鈥淩UI: Comparative Structure 鈥� Function Analysis of Phosphagen Kinases鈥� with Paul Edmiston and Dean Fraga (Biology).
Want to learn more?
Interested in Chemistry, Biochemistry and Molecular Biology or have questions about courses? Feel free to reach out!
Contact Mark